At first, I thought it was directed toward Jay-Z, but it's probably more of a diss to Lloyd Banks, since Game always pokes fun at how Banks is older than he says he is. Plus in the Hip-Hop Remix, Game says "140 thousand in your first week? Uhhhhh!" (which refers to what Banks' The Rotten Apple sold), so it's probably Banks then.
But I still think it's a subliminal to Jay, Game's been letting a few of those slip out.