Eliza Dushku plays a young woman called Echo, a member of a group of people known as "Actives" or "Dolls." The Dolls have had their personalities wiped clean so they can be imprinted with any number of new personas, including memory, muscle memory, skills, and language, for different assignments (referred to as engagements). The new persona is not an original creation, however, but an amalgam of different, existing personalities. The end result incorporates some of the flaws, not just the strengths, of the people used as templates. The Actives are then hired out for particular jobs -- crimes, fantasies, and the occasional good deed. On engagements, Actives are monitored internally (and remotely) by Handlers. In between tasks, they are mind-wiped into a child-like state and live in a futuristic dormitory/laboratory, a hidden facility nicknamed "The Dollhouse." The story follows Echo, who begins, in her mind-wiped state, to become self-aware.[3][4]
Beyond Dushku's character, the show also revolves around the people who run the mysterious "Dollhouse" and another "Doll," Sierra, who is friendly with Echo (the names are simply letters in the phonetic alphabet). Although the Actives are ostensibly volunteers, the operation is highly illegal and under constant threat on one end from Paul Ballard, a determined federal agent who has heard a rumor about the Dolls, and an insane rogue Active on the other.