Yes, it was a diss to Bone Thugs. After the situation between Dr. Dre and Eazy-E, Kurupt talked about "Ruthless fools" on What Would U Do. On Ruthless Radio, a bunch of Death Row artists (Daz, Kurupt, D.O.C., Michel'le) called in when Eazy was on and kept beefing (Daz was immature and stupid as usual), then at some point Layzie Bone started talking (since he was at the radio station along with a few other artists), saying how he was upset that they dissed the whole label with that line in What Would U Do. Kurupt's "hoes and harmony" line was probably fueled by that incident.