There are differences, I've played it on PS3 and Xbox360. I seem to get into it more on Xbox in addition the multiplayer is just better (cause of Xbox live). So it seals the deal for me.
I didn't bring up PES cause the recent ones sucked schlong (2009 and 10). The older ones were epic, especially the one on PS2, I forget... I think it was PES 6 with Adriano on the box. lol.
I enjoyed FIFA 10, but there is much that can be worked on... and I still don't get why they have the fucking Korean and Aussie league, but no Russian, Ukrainian, Romanian or Greek. Doesn't make sense lol.